First Cousin marriage risks genetic disorder

For Web Edition-First Cousin marriage risks- The genesMarrying your cousin may be legal but scientists have found it could significantly reduce genetic diversity, potentially leading to genetic disorders and lower fertility.

Although frowned on by many, including some religions, the only country in the Western World to outlaw first cousin marriage is the United States of America.

Author and poet Edgar Alan Poe, physicist Albert Einstein and, perhaps ironically, the author of the theory of evolution, naturalist Charles Darwin are among famous people in history to marry their cousins.

New Research

New research published in the journal ‘Molecular Biology and Evolution’ examined the relatively small population of the Rindi region on the Indonesian island of Sumba, where marriage rules dating back centuries dictate that men must marry a first cousin on the mother’s side of the family.

With a population of only about 7000, the scientific team, which includes experts from Indonesia, Singapore, the United States and New Zealand, expected to find significant biological effects of hundreds of generations following the rule.

They used a specially developed computer programme to run simulations to see how non-sex linked chromosomes (autosomes), the X and Y chromosomes and the DNA that is inherited only from the mother (mitochondrial DNA) would be affected if everyone followed the rule. They modelled it over many generations because the evidence suggests the practice is longstanding.

DNA Reflection

What they found was that arranged marriage should theoretically reduce the genetic diversity in those different DNA regions but what surprised them was that testing of the DNA in the current population did not reflect that.

It turned out the saving grace of the population is that the marriage rules are not strictly followed, either because it was not possible if a man’s mother had no siblings or no siblings with daughters, or because some men chose to ignore the rule – perhaps to forge alliances between families in other ways.

Senior author on the paper Associate Professor Murray Cox from Massey University’s Institute of Fundamental Sciences said that anthropologists have been studying the diverse range of marriage rules for the last century but this is the first study to try to understand any biological effects.

“Marriage rules help structure connections within and between communities but any rules that affect marriage will also have a direct impact on offspring and the genetics of a community. It is important to understand these genetic effects because reduced diversity might result in lower fertility, genetic disorders and potentially the loss of a community,” he said.

Problem Children

A 2013 paper published in ‘The Lancet’ found that babies of first cousin marriages were twice as likely to have a genetic disorder such as cleft palates, genital defects or problems with their nervous, respiratory and digestive systems.

However, this percentage was low at 6% and is comparable to the risk faced by children born to mothers over age 35.

The cultural practice of arranged marriage is common in areas like South Asia or the Middle East as well as some Western countries including New Zealand, the United Kingdom and the Netherlands where there are large populations from these regions.

The research was led by scientists from Massey University’s Institute of Fundamental Sciences, including PhD student Elsa Guillot, with scientists from the Eijkman Institute for Molecular Biology (Indonesia’s top genetic research centre), the Division of Biotechnology at the University of Arizona, United States, and the Complexity Institute at Nanyang Technological University, Singapore.

Source (Article and Picture): Massey News

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